Neuronal atg1 Coordinates Autophagy Induction and Physiological Adaptations to Balance mTORC1 Signalling

The mTORC1 nutrient-sensing pathway integrates metabolic and endocrine signals into the brain to evoke physiological responses food deprivation, such as autophagy. Nevertheless, impact of neuronal activity on circuits organismal metabolism remains obscure. Here, we show that inhibition acutely perturbs serotonergic neurotransmission via proteostatic alterations evoked by autophagy inducer atg1. Neuronal ATG1 alters intracellular localization serotonin transporter, which increases extracellular stimulates 5HTR7 postsynaptic receptor. enhances food-searching behaviour ecdysone-induced catabolism in Drosophila. Along similar lines, pharmacological zebrafish also activity. These effects occur parallel with induction, irrespective autophagic protein synthesis reduction. In addition, ectopic atg1 expression insulin downregulation, impedes peptidergic secretion, activates non-cell autonomous cAMP/PKA. above exert diverse systemic metabolism, development, melanisation, longevity. We conclude aligns induction distinct modulations, orchestrate a coordinated response against reduced